Upper limits of intraocular pressure in glaucoma clinical trials
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چکیده
منابع مشابه
Upper limits of intraocular pressure in glaucoma clinical trials.
The parallel, randomized, double-masked, activecontrolled trial is generally thought to be the most rigorous and unbiased design to adequately compare two glaucoma medicines. Important to this design is the intraocular pressure entry criteria. The lower limit of intraocular pressure is usually set at least >21 mmHg to help assure the study population has the appropriate diagnosis (ocular hypert...
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PURPOSE To determine the association of the lower limit of intraocular pressure (IOP) specified in the inclusion criteria to baseline and active treatment visit IOPs for monotherapy treatments. METHODS A review of clinical trial articles evaluating currently used topical glaucoma medicines. Articles were published between January 1995 and December 2011. RESULTS This study included 37 monoth...
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PURPOSE To evaluate methods which account for both eyes as a single, independent variable in glaucoma clinical trials. METHODS A review of clinical trial articles published between January 1995 and April 2011 evaluating currently used topical glaucoma medications. RESULTS This analysis included 17 articles with 36 treatment arms of which 14 were prostaglandins, 13 β-blockers, 6 topical carb...
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IMPORTANCE Little is known about the necessity of multiple same-day intraocular pressure (IOP) measurements in describing the effect of IOP-lowering surgical procedures, and such evidence could affect surgical trial recruitment and retention of participants. OBJECTIVE To determine whether a single IOP measurement might adequately approximate the mean of several measurements in glaucoma surgic...
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Background: To evaluate the agreement in intraocular pressure (IOP) measurements by Ocular Response Analyzer (ORA) and Tono-Pen XL (TXL) with the Goldmann Applanation Tonometer (GAT) and to examine corneal biomechanical properties in aphakic glaucoma patients with a central corneal thickness (CCT) >600 µ. Methods: Thirty-six eyes of aphakic glaucoma patients (group 1) and 40 eyes of normal chil...
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ژورنال
عنوان ژورنال: Clinical & Experimental Ophthalmology
سال: 2014
ISSN: 1442-6404
DOI: 10.1111/ceo.12357